The effect of myxomatous mitral valve disease severity on packed cell volume in dogs

Objectives The aim of this study was to examine whether associations between disease severity and packed cell volume exist in dogs with myxomatous mitral valve disease. Materials Methods Data were selected from 289 that had been examined at a research clinic (2004–2017) on multiple occasions (n=1465). American College Veterinary Internal Medicine stage echocardiographic measurements entered separate multivariable linear mixed effects models as the dependent variable. Age, breed, sex, weight blood urea nitrogen concentrations additionally tested these analyses control for patient characteristics. Results Packed (% whole blood) stages B1 B2 (B1: 42.62 ±0.27, P=0.001; B2: 41.77± 0.42, P < 0.001) lower than A (44.57 ±0.53). In C, greater both preclinical (C: 43.84 ±0.46). When administration loop diuretics included statistical models, inversely related normalised left ventricular internal diameters (β: −2.37; 95% confidence intervals: −3.49, −1.25; 0.001). Clinical Significance Dogs may develop reductions their progresses. Although finding statistically significant population level, it should be noted differences described are relatively small. This, along other causes variation volume, means changes would challenging appreciate within individual patients. Plasma depletion following diuretic explain why findings differed C.